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September 22, 2001BMJOpen Access

Antidepressants as risk factor for ischaemic heart disease: case-control study in primary care

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Why the study?

Does the use of antidepressants increase the risk of ischaemic heart disease in primary care patients?

Population

933 men and women with ischaemic heart disease matched by age, sex, and practice to 5,516 controls from nine…

Comparison

Prescription of antidepressants, including… vs Matched controls without ischaemic heart disease.

Design

Case-control

Authors

JHJulia Hippisley‐CoxUniversity of NottinghamMPM PringleUniversity of NottinghamVHVicky HammersleyUniversity of Edinburgh

Discussion

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Implication

Dosulepin was associated with higher IHD odds in primary care; hypothesis-generating and should not yet change practice without prospective confirmation.

Structured PICO

Does the use of antidepressants increase the risk of ischaemic heart disease in primary care patients?

P
Population
933 men and women with ischaemic heart disease matched by age, sex, and practice to 5,516 controls from nine general practices.
I
Intervention
Prescription of antidepressants, including tricyclic antidepressants (specifically dosulepin, amitriptyline, lofepramine) and selective serotonin reuptake inhibitors (SSRIs).
C
Comparator
Matched controls (by age, sex, and practice) without ischaemic heart disease.
O
Outcome
Ischaemic heart diseasehard clinical

The tricyclic antidepressant dosulepin is associated with a dose-dependent increased risk of ischaemic heart disease, whereas SSRIs and other TCAs like amitriptyline did not show a significant association.

Cite This Study

Hippisley‐Cox et al. (2001) studied this question.

synapsesocial.com/papers/6a7d4db5ade38b7dc346dc42https://doi.org/10.1136/bmj.323.7314.666

Topics

Women and heart disease
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Depression as a risk factor for ischaemic heart disease in men: population based case-control study1998 · 203 citations
  2. 2Is the Use of Psychotropic Drugs Associated with Increased Risk of Ischemic Heart Disease?1995 · 45 citations
  3. 3Risks of Antidepressants in the Elderly: Tricyclic Antidepressants and Arrhythmia – Revising Risks2009 · 43 citations
  4. 4Major depressive disorder predicts cardiac events in patients with coronary artery disease.1988 · 680 citations
  5. 5Depression, Psychotropic Medication, and Risk of Myocardial Infarction1996 · 644 citations