What question did this study set out to answer?

To evaluate the clinical efficacy of a single oral dose of azithromycin compared to single-dose intramuscular ceftriaxone for treating chancroid.

August 1, 1995Clinical Infectious Diseases

Comparison of Azithromycin and Ceftriaxone for the Treatment of Chancroid

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Authors

DMDavid H. MartinStatens Serum Institut SSSusie SargentLa Roche College GWGeorge D. WendelThe University of Texas Southwestern Medical Center

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Implication

Randomized trial demonstrates single-dose oral azithromycin cures chancroid as effectively as intramuscular ceftriaxone, highlighting a viable oral therapy.

Key Points

To evaluate the clinical efficacy of a single oral dose of azithromycin compared to single-dose intramuscular ceftriaxone for treating chancroid.
Randomized, unblinded, prospective trial enrolling 133 patients aged 16 years and older with darkfield-negative genital ulcers clinically suspected of being chancroid.
Participants received either a single 1-g oral dose of azithromycin or a single 250-mg intramuscular dose of ceftriaxone and were followed for up to 23 days.
Among culture-positive Haemophilus ducreyi cases, clinical cure was achieved in 100% (32/32) of patients treated with azithromycin, compared to clinical improvement or cure in 100% (33/33) treated with ceftriaxone.
Both single-dose regimens showed equivalent ulcer-healing rates among the 68 patients whose cultures were negative for both H. ducreyi and herpes simplex virus.

Cite This Study

Martin et al. (1995) studied this question.

synapsesocial.com/papers/6a7d4de1b0b0e582d537dbe5 https://doi.org/10.1093/clinids/21.2.409

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Implication

Randomized trial demonstrates single-dose oral azithromycin cures chancroid as effectively as intramuscular ceftriaxone, highlighting a viable oral therapy.

Comparison of Azithromycin and Ceftriaxone for the Treatment of Chancroid

Discussion

Member takes

Implication

Key Points

Cite This Study

Comparison of Azithromycin and Ceftriaxone for the Treatment of Chancroid

Discussion

Member takes

Implication

Key Points

Cite This Study

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