What question did this study set out to answer?

To develop and evaluate a parametric digital subtraction angiography method for generating two-dimensional functional images of coronary flow reserve.

February 1, 1987Circulation

Digital subtraction angiographic imaging of coronary flow reserve.

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Why the study?

Does digital subtraction angiographic imaging accurately measure coronary flow reserve compared to electromagnetic flowmeter in a canine model?

Population

Open-chest canine preparation (dogs)

Comparison

Digital subtraction angiographic imaging of… vs Electromagnetic flowmeter measurements

Design

Preclinical

Authors

JCJack T. CusmaMayo Clinic in Arizona ETEdward J. ToggartSamaritan Health Services JFJohn D. FoltsGeneral / Preventive / Lipids

Discussion

Member takes

Implication

Strong correlation with flowmeter in canines supports method feasibility; leaves open human validation and clinical adoption.

Key Points

To develop and evaluate a parametric digital subtraction angiography method for generating two-dimensional functional images of coronary flow reserve.
Acquired cardiac phase-matched digital subtraction angiographic images before and after hyperemic intervention in an open-chest canine model.
Applied linear temporal interpolation to subtraction image sequences to generate two-dimensional parametric flow ratio images.
Correlated image-derived coronary flow reserve values within the perfusion bed against standard electromagnetic flowmeter measurements using linear regression.
Parametric image flow ratio values correlated strongly with electromagnetic flowmeter measurements, demonstrating a linear regression fit of y = 0.96x - 0.19 and a correlation coefficient of r = 0.90.
Summation of flow variables within the perfusion bed enabled quantitative characterization of the functional significance of isolated arterial lesions.

Structured PICO

Does digital subtraction angiographic imaging accurately measure coronary flow reserve compared to electromagnetic flowmeter in a canine model?

Population

Open-chest canine preparation (dogs)

Intervention

Digital subtraction angiographic imaging of coronary flow reserve (parametric images obtained before and after hyperemic intervention)

Comparator

Electromagnetic flowmeter measurements

Outcome

Correlation between parametric image flow ratio values and electromagnetic flowmeter measurementssurrogate

Digital subtraction angiographic imaging provides a two-dimensional display of coronary flow reserve that correlates well with electromagnetic flowmeter measurements in a canine model.

Cite This Study

Cusma et al. (1987) studied this question.

synapsesocial.com/papers/6a7d4e2d1e40f448689660ae https://doi.org/10.1161/01.cir.75.2.461

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Digital subtraction angiographic imaging of coronary flow reserve.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Digital subtraction angiographic imaging of coronary flow reserve.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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