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Summarize the structural biology, enzymatic mechanisms, and physiological signaling roles of CD38 and related ADP-ribosyl cyclase superfamily members.

May 1, 2004Current Molecular Medicine

Structure and Enzymology of ADP-ribosyl Cyclases: Conserved Enzymes that Produce Multiple Calcium Mobilizing Metabolites

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Authors

FSFrancis SchuberCentre National de la Recherche Scientifique FLFrances E. LundUniversity of Alabama at Birmingham

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Implication

Review details the catalytic mechanisms and structure of CD38 in mammalian cells, highlighting its potential as a therapeutic target for inflammatory diseases.

Key Points

Summarize the structural biology, enzymatic mechanisms, and physiological signaling roles of CD38 and related ADP-ribosyl cyclase superfamily members.
Analyzed structural data from X-ray crystallography of ADP-ribosyl cyclases from Aplysia californica and mammalian homologs (CD38 and CD157).
Evaluated site-directed mutagenesis studies and kinetic models characterizing the catalytic conversion of NAD+ to cyclic ADP-ribose.
Reviewed cellular and in vivo evidence detailing CD38 involvement in chemokine-mediated calcium signaling and immune cell trafficking.
X-ray crystallographic and mutagenesis studies identified the structural topology of the CD38 active site and the catalytic residues essential for transforming NAD+ into cyclic ADP-ribose.
Cyclic ADP-ribose generated by CD38 regulates downstream calcium release following chemokine receptor activation, which is required for leukocyte migration to sites of inflammation.
Identification of the substrate-binding pocket and kinetic reaction intermediates provides a structural basis for the rational design of CD38-specific inhibitors.

Cite This Study

Schuber et al. (2004) studied this question.

synapsesocial.com/papers/6a7d4f143575152c8237dd92 https://doi.org/10.2174/1566524043360708

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Implication

Review details the catalytic mechanisms and structure of CD38 in mammalian cells, highlighting its potential as a therapeutic target for inflammatory diseases.

Structure and Enzymology of ADP-ribosyl Cyclases: Conserved Enzymes that Produce Multiple Calcium Mobilizing Metabolites

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Implication

Key Points

Cite This Study

Structure and Enzymology of ADP-ribosyl Cyclases: Conserved Enzymes that Produce Multiple Calcium Mobilizing Metabolites

Discussion

Member takes

Implication

Key Points

Cite This Study

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