Why the study?
NFATC1 has been implicated in cardiac valve formation in humans and mice, but little is known about the underlying mechanisms.
Nfatc1 is essential for valve interstitial cell formation and proper cardiac valve development in zebrafish, with its loss leading to persistent valvular dysfunction.
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Zebrafish data do not inform clinical valve care; leaves open Nfatc1 relevance to human valve interstitial cell formation.
Gunawan et al. (2020) studied this question.
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