Population
Murine developing heart model (embryonic day 8.5 to 12.5) and pro-valve endocardial cells
Comparison
Deletion analysis and mutation of the Nfatc1… vs Wild-type enhancer sequences
Design
Preclinical
Authors
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No clinical implications from this animal study; leaves open whether Nfatc1 enhancer modulation affects human valve development.
Identification of an autonomous cell-specific enhancer reveals a unique transcriptional mechanism regulating Nfatc1 expression during cardiac valve development.
Zhou et al. (2005) studied this question.
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