Why the study?
Does thrombolysis cause severe embolic complications in patients with acute myocardial infarction?
Does thrombolysis cause severe embolic complications in patients with acute myocardial infarction?
Thrombolysis in acute myocardial infarction can cause severe, potentially fatal embolic complications due to disintegration of pre-existing clots, suggesting conditions like enlarged left atrium or aneurysms should be considered contraindications.
Thrombolysis was associated with severe embolic complications in AMI; leaves open whether pre-existing clots warrant new contraindications.
Seven of 475 consecutive patients treated with thrombolysis for acute myocardial infarction had severe embolic complications that were believed to be caused by disintegration of pre-existing clot. Three patients had symptoms that persisted for many weeks, and five died. Any potential site of pre-existing blood clot within the vascular system, notably an enlarged left atrium, ventricular aneurysm, or aortic aneurysms, should be regarded as a contraindication to treatment with thrombolytic agents.
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Stafford et al. (1989) studied this question.
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