Why the study?
Can underlying Hashimoto's thyroiditis precipitate rhabdomyolysis in patients on statin therapy?
Can underlying Hashimoto's thyroiditis precipitate rhabdomyolysis in patients on statin therapy?
Underlying Hashimoto's thyroiditis can precipitate statin-induced rhabdomyolysis, highlighting the importance of evaluating thyroid function in patients presenting with statin-associated severe muscle symptoms.
Answers are grounded in this paper and cite their sources.
May precipitate statin rhabdomyolysis in Hashimoto's; hypothesis-generating case leaves screening value open.
Hashimoto's thyroiditis (HT) or chronic lymphocytic thyroiditis is the most common form of primary hypothyroidism. Muscular manifestations like weakness, pain, stiffness and elevated muscle enzymes have been noticed in hypothyroidism. Statins are also known to cause myositis and rhabdomyolysis. This is a case of a middle-aged man, on statin therapy, who presented with severe muscle aches and pain and was found to have rhabdomyolysis. Further evaluation revealed an underlying HT as the culprit for his condition. He was managed with intravenous fluids and levothyroxine along with cessation of statins, following which he improved.
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Peringat et al. (2018) studied this question.
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