Why the study?
Does current use of low-dose oral contraceptives increase the risk of nonfatal first myocardial infarction in women younger than 45 years?
Population
3,574 women younger than 45 years, comprising 627 with a nonfatal first myocardial infarction and 2,947…
Comparison
Current use of low-dose oral contraceptives vs Never used oral contraceptives
Design
Case-control
Authors
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OC use with heavy smoking was associated with high MI odds in young women; leaves open independent risk in nonsmokers and requires prospective confirmation.
Does current use of low-dose oral contraceptives increase the risk of nonfatal first myocardial infarction in women younger than 45 years?
Current use of low-dose oral contraceptives does not increase the risk of myocardial infarction in young women who are nonsmokers or light smokers, but synergistically increases the risk in heavy smokers.
Rosenberg et al. (2001) studied this question.
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