Why the study?
Does apolipoprotein C3 deficiency accelerate diet-induced obesity and insulin resistance in mice?
Population
Apoc3(-/-) mice and wild-type littermates
Comparison
High-fat (46 energy %) diet for 20 weeks vs Wild-type littermates on the same high-fat diet
Design
Preclinical
Follow-up
20 weeks
Authors
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ApoC3 deficiency may promote diet-induced obesity in mice despite lowering triglycerides; hypothesis-generating and should not change clinical practice.
Does apolipoprotein C3 deficiency accelerate diet-induced obesity and insulin resistance in mice?
Absence of apoC3 enhances fatty acid uptake from plasma triglycerides in adipose tissue, leading to higher susceptibility to diet-induced obesity and more severe insulin resistance in mice.
Duivenvoorden et al. (2005) studied this question.
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