Pivotal Role of Serum- and Glucocorticoid-Inducible Kinase 1 in Vascular Inflammation and Atherogenesis

Oliver Borst; Malte Schaub; Britta Walker; Evi Schmid; Patrick Münzer; Jakob Voelkl; Ioana Alesutan; José María Ros Rodríguez; Sebastian Vogel; Tanja Schoenberger; Katja Metzger; Dominik Rath; Anja T. Umbach; Dietmar Kuhl; Iris Müller; Peter Seizer; Tobias Geisler; Meinrad Gawaz; Florian Läng

doi:10.1161/atvbaha.114.304454

Structured PICO

P

Population

Gene-targeted apolipoprotein E (ApoE)-deficient mice and THP-1 cells

I

Intervention

SGK1 knockout (apoe(-/-)sgk1(-/-)) and 16-week cholesterol-rich diet; in vitro SGK1 transfection or inhibition

C

Comparator

apoe(-/-)sgk1(+/+) mice on 16-week cholesterol-rich diet; control plasmid-transfected or inactive SGK1-transfected THP-1 cells

O

Outcome

Atherosclerotic lesions in aorta and carotid artery, vascular CD45(+) leukocyte infiltration, Mac-3(+) macrophage infiltration, vascular smooth muscle cell content, MMP-2, and MMP-9 positive areassurrogate

SGK1 plays a pivotal role in vascular inflammation and atherogenesis by regulating monocyte/macrophage migration and MMP-9 transcription via NF-κB.

Implication

SGK1 may be a viable therapeutic target; leaves open translation from this mouse model to patients.

Discussion

No takes yet. Share an insight, caveat, or question.

Cite This Study

Borst et al. (2015) studied this question.

synapsesocial.com/papers/6a7d63ea274d9b3610aa0b40 https://doi.org/10.1161/atvbaha.114.304454

View Full Paper

Ask AI

Bookmark

Share

Pivotal Role of Serum- and Glucocorticoid-Inducible Kinase 1 in Vascular Inflammation and Atherogenesis

Structured PICO

Implication

Discussion

Cite This Study

Pivotal Role of Serum- and Glucocorticoid-Inducible Kinase 1 in Vascular Inflammation and Atherogenesis

Structured PICO

Implication

Discussion

Cite This Study

Keep reading

Keep reading