What question did this study set out to answer?

To determine the clinicopathological significance of histone methyltransferase G9a in ovarian cancer and evaluate its functional role and molecular targets during peritoneal metastasis.

August 12, 2014Molecular CancerOpen Access

The H3K9 methyltransferase G9a is a marker of aggressive ovarian cancer that promotes peritoneal metastasis

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To determine the clinicopathological significance of histone methyltransferase G9a in ovarian cancer and evaluate its functional role and molecular targets during peritoneal metastasis.
Assessed G9a expression across human ovarian cancer specimens, comparing primary tumors against corresponding peritoneal metastatic lesions.
Manipulated G9a expression in ovarian cancer cell lines via knockdown and overexpression to evaluate effects on adhesion, migration, invasion, anoikis-resistance, and intraperitoneal xenograft tumor formation in mice.
Profiled G9a-regulated downstream target genes using microarray analysis and quantitative reverse transcription PCR.
Elevated G9a expression correlated with late-stage, high-grade, serous-type ovarian cancer and reduced overall patient survival, with higher expression observed in metastatic lesions than primary tumors.
G9a depletion suppressed in vitro cancer cell adhesion, migration, invasion, and anoikis-resistance, while significantly diminishing peritoneal ascites volume and tumor nodule dissemination in xenograft models.
G9a negatively regulated and repressed expression of multiple tumor suppressor genes, specifically CDH1, DUSP5, SPRY4, and PPP1R15A, in ovarian cancer cell lines and clinical specimens.

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Implication

Translational study reveals that G9a promotes peritoneal metastasis and suppresses tumor suppressor genes in ovarian cancer, highlighting its therapeutic potential.

Cite This Study

Hua et al. (2014) studied this question.

synapsesocial.com/papers/6a7d641dd3686d25b46e5a6a https://doi.org/10.1186/1476-4598-13-189

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Implication

Translational study reveals that G9a promotes peritoneal metastasis and suppresses tumor suppressor genes in ovarian cancer, highlighting its therapeutic potential.

The H3K9 methyltransferase G9a is a marker of aggressive ovarian cancer that promotes peritoneal metastasis

Key Points

Discussion

Implication

Cite This Study

The H3K9 methyltransferase G9a is a marker of aggressive ovarian cancer that promotes peritoneal metastasis

Key Points

Discussion

Implication

Cite This Study

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