Why the study?
Does daily nighttime melatonin reduce ambulatory blood pressure in male patients with untreated essential hypertension?
Population
16 men with untreated essential hypertension
Comparison
Oral melatonin taken 1 hour before sleep… vs Matching placebo (crossover design)
Design
RCT, Randomized crossover, Double-blind
Follow-up
3 weeks
Authors
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Supports adjunctive melatonin for nocturnal BP control in untreated hypertension; extends circadian modulation evidence to ambulatory monitoring.
Does daily nighttime melatonin reduce ambulatory blood pressure in male patients with untreated essential hypertension?
Repeated nighttime melatonin intake significantly reduces nocturnal blood pressure and improves sleep in men with untreated essential hypertension, suggesting a potential role for circadian pacemaker support in hypertension management.
Scheer et al. (2004) studied this question.
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