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April 1, 2003Transplantation

Health-related quality-of-life outcomes of sirolimus-treated kidney transplant patients after elimination of cyclosporine A: results of a 2-year randomized clinical trial1

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Why the study?

Does elimination of cyclosporine A improve health-related quality-of-life in kidney transplant patients on sirolimus-based therapy?

Population

430 kidney transplant patients after 3 months of combined sirolimus, cyclosporine A, and steroids treatment

Comparison

Sirolimus plus steroids vs Sirolimus, cyclosporine A, and steroids

Design

RCT, randomly assigned, open-label

Follow-up

2 years

Authors

RORainer OberbauerMedical University of ViennaBHBrian HutchisonAtrium Health Wake Forest BaptistJEJosette ErisThe University of Sydney

Discussion

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Implication

Supports early cyclosporine elimination in sirolimus regimens for kidney transplant QoL gains; extends RCT evidence to fatigue and vitality domains.

Structured PICO

Does elimination of cyclosporine A improve health-related quality-of-life in kidney transplant patients on sirolimus-based therapy?

P
Population
430 kidney transplant patients after 3 months of combined sirolimus, cyclosporine A, and steroids treatment
I
Intervention
Sirolimus plus steroids (elimination of cyclosporine A)
C
Comparator
Sirolimus, cyclosporine A, and steroids (continuous treatment)
O
Outcome
Health-related quality-of-life (HRQL) measured using the Kidney Transplant Questionnaire (KTQ) and the SF-36 Health Survey over a 2-year periodpatient reported

Early elimination of cyclosporine A from a sirolimus-based regimen improves fatigue, vitality, and appearance-related quality of life in kidney transplant recipients.

Cite This Study

Oberbauer et al. (2003) studied this question.

synapsesocial.com/papers/6a7d64b2ec6dad7f5aaa17a9https://doi.org/10.1097/01.tp.0000061766.37366.6b
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Induction of Monocyte Chemoattractant Protein-1 by Albumin Is Mediated by Nuclear Factor κB in Proximal Tubule Cells1999 · 209 citations
  2. 2Disease-Specific Questionnaire for Patients with a Renal Transplant1993 · 94 citations
  3. 3The Quality of Life of Patients with End-Stage Renal Disease1985 · 1,195 citations
  4. 4Modelling covariance structure in the analysis of repeated measures data2000 · 936 citations
  5. 5Improved renal function in sirolimus-treated renal transplant patients after early cyclosporine elimination1, 22002 · 168 citations