EDITOR-We agree with Lemon and Dunnett that better methods of surveying the literature on animal experiments are needed,1 but we do not share their confidence in the utility of non-systematic reviews.In clinical trials, systematic review and meta-analysis have made important contributions to our understanding of sources of bias, and the quality of clinical trials has improved as a result.
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Macleod et al. (2005) studied this question.
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