September 13, 2011The Journal of PhysiologyOpen Access

Dietary nitrate reduces muscle metabolic perturbation and improves exercise tolerance in hypoxia

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Why the study?

Does dietary nitrate supplementation improve exercise tolerance and muscle metabolism in healthy subjects during hypoxia?

Structured PICO

Does dietary nitrate supplementation improve exercise tolerance and muscle metabolism in healthy subjects during hypoxia?

Population

9 healthy subjects

Intervention

0.75 L of nitrate-rich beetroot juice (9.3 mmol nitrate) consumed during 24 h prior to exercise in hypoxia (14.5% O2)

Comparator

0.75 L of nitrate-depleted beetroot juice (0.006 mmol nitrate) in hypoxia, and normoxia control (20.9% O2)

Outcome

Limit of tolerance (T(lim)) during knee-extension exercisesurrogate

Dietary nitrate supplementation restores exercise tolerance and muscle oxidative function during hypoxia to normoxic levels in healthy subjects.

Discussion

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Implication

Nitrate supplementation counters hypoxia-induced exercise limitation; extends prior normoxic benefits to oxygen-limited environments in healthy subjects.

Cite This Study

Vanhatalo et al. (2011) studied this question.

synapsesocial.com/papers/6a7d6652059d5906862793eb https://doi.org/10.1113/jphysiol.2011.216341

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Implication

Nitrate supplementation counters hypoxia-induced exercise limitation; extends prior normoxic benefits to oxygen-limited environments in healthy subjects.

Dietary nitrate reduces muscle metabolic perturbation and improves exercise tolerance in hypoxia

Structured PICO

Discussion

Implication

Cite This Study

Dietary nitrate reduces muscle metabolic perturbation and improves exercise tolerance in hypoxia

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider