Why the study?
What is the rate of decrease of the international normalized ratio (INR) after temporary discontinuation of warfarin therapy in outpatients?
Population
22 outpatients receiving a fixed evening dose of warfarin for whom temporary discontinuation of therapy was…
Design
Cohort
Follow-up
185 hours
Authors
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May inform perioperative warfarin timing in outpatients; leaves open prospective validation of age-adjusted protocols.
What is the rate of decrease of the international normalized ratio (INR) after temporary discontinuation of warfarin therapy in outpatients?
To achieve an INR <1.2 for surgery, warfarin should be withheld for 96 to 115 hours (4 doses) in patients with a steady-state INR of 2.0-3.0, with longer waits needed for older patients or those with higher baseline INRs.
Richard H. White (1995) studied this question.
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