Upregulation of fibronectin synthesis by interleukin-1 beta in coronary artery smooth muscle cells is associated with the development of the post-cardiac transplant arteriopathy in piglets.
Population
Cultured smooth muscle cells from donor and host coronary arteries of piglets after heterotopic cardiac…
Comparison
Neutralizing antibodies to IL-1 beta and IL-1… vs Host cells and untreated donor cells
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Does not support IL-1β blockade in transplant care; leaves open translation of this piglet mechanism to humans.
Structured PICO
P
Population
Cultured smooth muscle cells from donor and host coronary arteries of piglets after heterotopic cardiac transplantation
I
Intervention
Neutralizing antibodies to IL-1 beta and IL-1 receptor antagonist (in vitro)
C
Comparator
Host cells and untreated donor cells
O
Outcome
Fibronectin protein synthesis and mRNA levelssurrogate
In a piglet model, IL-1 beta mediates increased fibronectin synthesis in donor coronary artery smooth muscle cells, suggesting an autocrine mechanism contributing to post-cardiac transplant coronary arteriopathy.
Cite This Study
Clausell et al. (1993) studied this question.