July 13, 2014American Journal of HypertensionOpen Access

Progression of Kidney Injury and Cardiac Remodeling in Obese Spontaneously Hypertensive Rats: The Role of Renal Sympathetic Innervation

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Why the study?

Does renal sympathetic denervation attenuate the progression of blood pressure, renal injury, and cardiac remodeling in obese spontaneously hypertensive rats?

Population

Obese spontaneously hypertensive rats (SHRs-ob) at 34 weeks of age

Comparison

Renal sympathetic denervation (RDN) vs Sham-operated SHRs-ob and normotensive lean…

Design

Preclinical

Follow-up

14 weeks (from 34 to 48 weeks of age) / 100 days after RDN

Authors

DLDominik LinzElectrophysiology MHMathias HohlUniversitätsklinikum des Saarlandes JSJosephine SchützeCharité - Universitätsmedizin Berlin

Discussion

Member takes

Implication

Hypothesis-generating for RDN in obesity-hypertension; leaves open translation to human disease.

Structured PICO

Does renal sympathetic denervation attenuate the progression of blood pressure, renal injury, and cardiac remodeling in obese spontaneously hypertensive rats?

Population

Obese spontaneously hypertensive rats (SHRs-ob) at 34 weeks of age

Intervention

Renal sympathetic denervation (RDN)

Comparator

Sham-operated SHRs-ob and normotensive lean controls (Ctrs)

Outcome

Blood pressure, progression of renal injury (urinary albumin/creatinine ratio, glomerular filtration rate, renal perfusion), and cardiac remodeling (fibrosis and diastolic dysfunction)surrogate

Renal sympathetic denervation effectively attenuates the progressive increase in blood pressure, renal injury, and cardiac remodeling in a rat model of obesity and hypertension.

Cite This Study

Linz et al. (2014) studied this question.

synapsesocial.com/papers/6a7d6806469c795fc427a0c4 https://doi.org/10.1093/ajh/hpu123

Topics

Hypertension management

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