Population
Stroke-prone spontaneously hypertensive rats (SHRSP) subjected to salt loading
Comparison
Valsartan, hydralazine, or apocynin vs Vehicle
Design
Preclinical
Authors
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Indicates ARB benefit exceeds BP reduction via NADPH oxidase suppression in hypertensive stroke; hypothesis-generating in rats, leaves open human translation.
In a rat model of salt-induced hypertension, angiotensin II-activated NADPH oxidase mediates cerebral neuronal apoptosis and inflammation, which can be mitigated by valsartan.
Yamamoto et al. (2008) studied this question.
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