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February 1, 2003Diabetes CareOpen Access

The Potential Therapeutic Role of Insulin in Acute Myocardial Infarction in Patients Admitted to Intensive Care and in Those With Unspecified Hyperglycemia

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Why the study?

Does intravenous insulin improve clinical outcomes in patients with acute myocardial infarction and hyperglycemia?

Population

Patients with acute myocardial infarction admitted to intensive care and those with unspecified hyperglycemia

Design

Review

Authors

PDParesh DandonaAAAhmad AljadaABArindam Bandyopadhyay

Discussion

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Overview

Intravenous insulin effects beyond glucose control remain unproven for AMI or ICU hyperglycemia; leaves open need for isolating trials before any practice consideration.

Structured PICO

Does intravenous insulin improve clinical outcomes in patients with acute myocardial infarction and hyperglycemia?

P
Population
Patients with acute myocardial infarction admitted to intensive care and those with unspecified hyperglycemia
I
Intervention
Intravenous infusions of insulin

Insulin may offer therapeutic benefits in acute myocardial infarction and critical illness beyond glucose control by modulating inflammation and free fatty acid metabolism.

Cite This Study

Dandona et al. (2003) studied this question.

synapsesocial.com/papers/6a7d6b4cd685fe2c2d776270https://doi.org/10.2337/diacare.26.2.516
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Role of Free Fatty Acids in the Production of Ventricular Arrhythmias after Acute Coronary Artery Occlusion1971 · 190 citations
  2. 2In Vivo Myocardial Protection From Ischemia/Reperfusion Injury by the Peroxisome Proliferator–Activated Receptor-γ Agonist Rosiglitazone2001 · 296 citations
  3. 3Leukocyte-endothelial interaction is augmented by high glucose concentrations and hyperglycemia in a NF-kB-dependent fashion.1998 · 439 citations
  4. 4Determinants and importance of stress hyperglycaemia in non-diabetic patients with myocardial infarction.1986 · 269 citations
  5. 5Insulin Inhibits the Pro-Inflammatory Transcription Factor Early Growth Response Gene-1 (Egr)-1 Expression in Mononuclear Cells (MNC) and Reduces Plasma Tissue Factor (TF) and Plasminogen Activator Inhibitor-1 (PAI-1) Concentrations2002 · 250 citations