Population
Plasmacytoid dendritic cells (pDC) and cells infected with classical swine fever virus (a pestivirus)
Comparison
Viral E(rns) protein with ribonuclease activity vs Absence of E protein / direct stimulation by…
Design
Preclinical
Authors
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E(rns) ribonuclease activity may enable pestivirus persistence in animal models; leaves open relevance to human cell-associated viral infections.
The viral E(rns) protein of pestiviruses efficiently prevents pDC activation by infected cells, highlighting a mechanism of immune evasion for cell-associated, persistent viruses.
Python et al. (2013) studied this question.
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