Detection of enterovirus‐specific total and polymeric IgA antibodies in serum using a synthetic peptide or heated virion antigen in ELISA

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Why the study?

Does indirect ELISA using synthetic peptide or heated coxsackie B5 antigen accurately detect acute enterovirus infection?

Structured PICO

Does indirect ELISA using synthetic peptide or heated coxsackie B5 antigen accurately detect acute enterovirus infection?

Population

Patients with an acute enterovirus infection, patients with other infections, and healthy blood donors (summer and winter).

Intervention

Indirect ELISA using heated virions (coxsackie B5) and synthetic peptide to detect enterovirus-specific total and polymeric IgA antibodies

Outcome

Prevalence of enterovirus-specific total and polymeric IgA antibodiessurrogate

Total peptide-IgA and polymeric coxsackie B5-IgA detected via ELISA may serve as specific markers for acute enterovirus infection.

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IgA ELISA responses may mark acute enterovirus infection; leaves open diagnostic accuracy pending prospective validation.

Cello et al. (1994) studied this question.

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