What question did this study set out to answer?

To investigate the association between mean platelet volume (MPV) and the risk of stroke in patients diagnosed with atrial fibrillation.

October 18, 2012Blood Coagulation & Fibrinolysis

Usefulness of mean platelet volume for predicting stroke risk in atrial fibrillation patients

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Why the study?

Is high mean platelet volume associated with an increased risk of stroke in patients with atrial fibrillation?

Key Points

To investigate the association between mean platelet volume (MPV) and the risk of stroke in patients diagnosed with atrial fibrillation.
Analyzed 140 consecutive patients with atrial fibrillation admitted between January 2010 and April 2012, categorized into a stroke group (N=63) and a non-stroke history group (N=77).
Determined MPV levels within 24 hours of stroke onset and evaluated diagnostic performance using receiver-operating characteristic (ROC) curve analysis.
Determined an MPV cut-off value of 9.4 fl for detecting stroke, with a sensitivity of 63.5% and a specificity of 64.4%.
Observed that high MPV (>9.4 fl) was significantly associated with stroke occurrence (OR 4.021, 95% CI 1709-9464, P < 0.001).

Structured PICO

Is high mean platelet volume associated with an increased risk of stroke in patients with atrial fibrillation?

Population

140 consecutive patients with atrial fibrillation (63 with stroke history, 77 without stroke history) referred to a single center between January 2010 and April 2012.

Intervention

High mean platelet volume (>9.4 fl)

Comparator

Low mean platelet volume (≤9.4 fl)

Outcome

Occurrence of strokehard clinical

High mean platelet volume (>9.4 fl) may serve as a useful biomarker for identifying atrial fibrillation patients at increased risk of stroke.

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

Should not yet alter AF stroke risk assessment; hypothesis-generating and needs prospective validation.

Cite This Study

Turfan et al. (2012) studied this question.

synapsesocial.com/papers/6a7d6cccc7e6f6a50737d92d https://doi.org/10.1097/mbc.0b013e32835a0850

Topics

Atrial fibrillation Persistent AF management

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Usefulness of mean platelet volume for predicting stroke risk in atrial fibrillation patients

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Usefulness of mean platelet volume for predicting stroke risk in atrial fibrillation patients

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider