Why the study?
Mean platelet volume (MPV) is an identified risk factor for stroke and thrombosis, but its association with ischaemic stroke risk in nonvalvular AF patients not on anticoagulant therapy required investigation.
Does mean platelet volume predict ischaemic stroke in patients with nonvalvular atrial fibrillation not receiving anticoagulant therapy?
Does mean platelet volume predict ischaemic stroke in patients with nonvalvular atrial fibrillation not receiving anticoagulant therapy?
Mean platelet volume is a significant predictor of ischaemic stroke in patients with nonvalvular atrial fibrillation and improves the predictive value of the CHA2DS2-VASc score.
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Higher MPV may flag elevated stroke risk in untreated nonvalvular AF; leaves open whether adding it to CHA2DS2-VASc improves prospective stratification.
Zheng et al. (2020) studied this question.
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