Key result
High mean platelet volume (≥7.0 fL) was an independent predictor of ischemic stroke or left atrial thrombus in patients with nonvalvular atrial fibrillation (HR 6.408; 95% CI 2.874-14.286).
Why the study?
Do high mean platelet volume and antithrombin III deficiency predict stroke or left atrial thrombus in patients with nonvalvular atrial fibrillation?
Observational (n=352)
Do high mean platelet volume and antithrombin III deficiency predict stroke or left atrial thrombus in patients with nonvalvular atrial fibrillation?
Hazard Ratio: 6.408 (95% CI 2.874–14.286)
High mean platelet volume is an independent predictor of stroke or left atrial thrombus in patients with nonvalvular atrial fibrillation, independent of traditional risk scores.
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Suggests mean platelet volume may refine stroke risk stratification beyond traditional scores in atrial fibrillation; leaves open.
Choi et al. (2017) conducted an observational in nonvalvular atrial fibrillation (n=352). High mean platelet volume (≥7.0 fL) vs. Low mean platelet volume (<7.0 fL) was evaluated on composite of ischemic stroke event and incidental LA thrombus (HR 6.408, 95% CI 2.874-14.286). High mean platelet volume (≥7.0 fL) was an independent predictor of ischemic stroke or left atrial thrombus in patients with nonvalvular atrial fibrillation (HR 6.408; 95% CI 2.874-14.286).
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