Humoral Factors Affecting Pulmonary Inflation During Acute Anaphylaxis in the Guinea‐pig in Vivo

For more than 50 years, intense bronchoconstriction has been recognized as the cardinal feature of anaphylactic shock in the guinea-pig (Auer & Lewis, 1910; Biedl & Kraus, 1910). That the bronchoconstrictor response to antigen occurs without the nervous system (Auer & Lewis, 1910) and in isolated lung The finding that histamine is liberated in anaphylaxis of isolated guinea-pig lung This suggestion gains support from the findings that antihistamine drugs reduce the broncho- constrictor response to antigen given either by injection