Why the study?
Does temocapril reduce the severity of experimental autoimmune myocarditis in rats?
Population
Normal rat myocytes in vitro and in vivo, and rats with experimental autoimmune myocarditis (EAM)
Comparison
Temocapril 10 mg/kg/day orally from day 1 to day… vs Control/untreated (implied)
Design
Preclinical
Follow-up
21 days
Authors
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No clinical implications for myocarditis yet; leaves open timing-dependent effects of ACE inhibition in experimental models.
Does temocapril reduce the severity of experimental autoimmune myocarditis in rats?
Temocapril ameliorates experimental autoimmune myocarditis in rats, likely through preconditioning up-regulation of thioredoxin.
Zuyi Yuan (2002) studied this question.
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