May 13, 1997Proceedings of the National Academy of SciencesOpen Access

Molecular cloning, sequence, expression, and processing of the interleukin 16 precursor

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Population

COS-7 cells, CD8(+) cell lysates, and lymphatic tissues

Design

Preclinical

Authors

MBMichael BaierUniversitätsklinik Marien Hospital Herne NBNorbert BannertRobert Koch Institute AWAlbrecht WernerDiakonissenkrankenhaus

Discussion

Member takes

Implication

No immediate clinical implications; extends basic IL-16 biosynthesis knowledge but leaves open any human disease relevance.

Structured PICO

Population

COS-7 cells, CD8(+) cell lysates, and lymphatic tissues

Intervention

Molecular cloning, sequencing, and expression of pro-IL-16 cDNA

Outcome

Identification of the transcriptional start, cloning of complete pro-IL-16 cDNA, and characterization of its expression and processing

The study identifies the true transcriptional start of IL-16 mRNA and demonstrates that pro-IL-16 is synthesized as a 67-kDa precursor that is cleaved into a smaller bioactive form.

Cite This Study

Baier et al. (1997) studied this question.

synapsesocial.com/papers/6a7d72b586b21ee5f583dc1b https://doi.org/10.1073/pnas.94.10.5273

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Molecular cloning, sequence, expression, and processing of the interleukin 16 precursor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Molecular cloning, sequence, expression, and processing of the interleukin 16 precursor

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider