Population
Animal models under baseline conditions, elevated tone conditions, and with monocrotaline-induced pulmonary…
Comparison
Intravenous injections of the soluble guanylyl… vs Sodium nitroprusside and BAY 41-8543
Design
Preclinical
Authors
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BAY 60-2770 lacks pulmonary selectivity in rat PH models; leaves open whether sGC activators confer clinical benefit over nonselective agents.
The sGC activator BAY 60-2770 promotes NO-independent vasodilation in vivo, but lacks selective pulmonary vasodilator activity in monocrotaline-induced pulmonary hypertension models.
Pankey et al. (2011) studied this question.
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