Why the study?
Does inhalation of sGC stimulators or activators produce selective pulmonary vasodilation in lambs with acute pulmonary hypertension?
Does inhalation of sGC stimulators or activators produce selective pulmonary vasodilation in lambs with acute pulmonary hypertension?
Inhaled microparticles containing sGC agonists produce selective pulmonary vasodilation in a lamb model of acute pulmonary hypertension, even when responsiveness to nitric oxide is impaired.
Hypothesis-generating for inhaled sGC agonists in acute PH; extends animal data but leaves clinical translation open.
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Evgenov et al. (2007) studied this question.
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