Why the study?
Does sildenafil improve endothelial dysfunction and hypertension in spontaneously hypertensive rats?
Population
13-week-old male spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto rats
Comparison
Sildenafil 2.5 mg/kg/day by gastric gavage for 6… vs Vehicle by gastric gavage for 6 months
Design
Preclinical
Follow-up
6 months
Authors
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Supports PDE5 inhibition in experimental hypertension models; leaves open translation to human essential hypertension.
Does sildenafil improve endothelial dysfunction and hypertension in spontaneously hypertensive rats?
Long-term sildenafil treatment reverses endothelial dysfunction and ameliorates hypertension in spontaneously hypertensive rats, suggesting potential as an adjunct therapy in essential hypertension.
Yaguas et al. (2010) studied this question.
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