What question did this study set out to answer?

To develop and validate a simple clinical prediction score for identifying small-cell lung cancer early in the course of Lambert-Eaton myasthenic syndrome.

January 19, 2011Journal of Clinical OncologyOpen Access

Clinical Dutch-English Lambert-Eaton Myasthenic Syndrome (LEMS) Tumor Association Prediction Score Accurately Predicts Small-Cell Lung Cancer in the LEMS

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To develop and validate a simple clinical prediction score for identifying small-cell lung cancer early in the course of Lambert-Eaton myasthenic syndrome.
Derived a risk score using multivariate logistic regression in a nationwide derivation cohort of 107 Dutch patients with Lambert-Eaton myasthenic syndrome (LEMS).
Validated the Dutch-English LEMS Tumor Association Prediction (DELTA-P) score in an independent cohort of 112 British patients with LEMS.
Assigned one point for each of six clinical factors present at or within 3 months of onset: age ≥ 50 years, smoking at diagnosis, weight loss ≥ 5%, bulbar involvement, erectile dysfunction, and Karnofsky performance status < 70.
The DELTA-P score showed high discrimination, with an area under the receiver operating characteristic curve of 94.4% in the derivation cohort and 94.6% in the validation cohort.
Patients with a score of 0 or 1 had a 0% to 2.6% risk of small-cell lung cancer.
Patients with scores of 4, 5, and 6 had a 93.5%, 96.6%, and 100% chance of small-cell lung cancer, respectively.

Authors

MTMaarten J. TitulaerUniversité Claude Bernard Lyon 1 PMPaul MaddisonNottingham University Hospitals NHS Trust JSJacob K. SontLeiden University Medical Center

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Implication

Cohort study reveals a clinical prediction score accurately identifies small-cell lung cancer in Lambert-Eaton myasthenic syndrome, suggesting rapid risk stratification early in disease course.

Cite This Study

Titulaer et al. (2011) studied this question.

synapsesocial.com/papers/6a7d75dee9ddcd9870aa21bd https://doi.org/10.1200/jco.2010.32.0440

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Implication

Cohort study reveals a clinical prediction score accurately identifies small-cell lung cancer in Lambert-Eaton myasthenic syndrome, suggesting rapid risk stratification early in disease course.

Clinical Dutch-English Lambert-Eaton Myasthenic Syndrome (LEMS) Tumor Association Prediction Score Accurately Predicts Small-Cell Lung Cancer in the LEMS

Key Points

Discussion

Implication

Cite This Study

Clinical Dutch-English Lambert-Eaton Myasthenic Syndrome (LEMS) Tumor Association Prediction Score Accurately Predicts Small-Cell Lung Cancer in the LEMS

Key Points

Discussion

Implication

Cite This Study

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