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This meta-analysis evaluates the relationship between weight loss and survival outcomes in esophageal cancer patients.

Association between Weight Loss and Survival Outcomes in Patients with Esophageal Cancer: A Meta-Analysis

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Meta-analysis finds weight loss negatively affects survival in esophageal cancer patients, suggesting crucial implications.

This meta-analysis evaluates the relationship between weight loss and survival outcomes in esophageal cancer patients.
Systematic search of PubMed, Embase, and Web of Science for relevant studies.
Included 11 studies involving 3,566 esophageal cancer patients.
Calculated pooled adjusted hazard ratios (HR) and 95% confidence intervals (CI) using a random-effects model.
Weight loss associated with poorer overall survival (HR 1.68; 95% CI 1.49-1.90).
Weight loss linked to poorer progression-free survival (HR 1.61; 95% CI 1.39-1.86).
Higher HR for overall survival noted in patients aged 60 years or younger and those assessed during treatment.

A 2026 study studied this question.

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