Why the study?
Does lidoflazine improve survival or neurologic recovery in comatose survivors of cardiac arrest?
Population
n=520 patients with cardiac arrest who remained comatose after the restoration of spontaneous circulation
Comparison
Lidoflazine vs Placebo
Design
RCT, randomly assigned, investigators were blinded to treatment assignment
Follow-up
six months
Authors
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Lidoflazine confers no benefit in comatose arrest survivors; confirms neutral effect and redirects research away from this agent.
Does lidoflazine improve survival or neurologic recovery in comatose survivors of cardiac arrest?
Lidoflazine administration does not improve survival or neurologic outcomes in comatose survivors of cardiac arrest.
Brain Resuscitation Clinical Trial II Study Group (1991) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: