What question did this study set out to answer?

The aim is to characterize neutrophil states in the liver microenvironment of primary sclerosing cholangitis (PSC).

Single-cell landscape of neutrophil activation in primary sclerosing cholangitis

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Randomized trial defines neutrophil activation in PSC livers, indicating targets for therapy.

The aim is to characterize neutrophil states in the liver microenvironment of primary sclerosing cholangitis (PSC).
Conducted single-cell RNA sequencing on leukocytes from liver perfusate of healthy donors and PSC patients.
Identified diverse neutrophil subclusters in PSC liver perfusate.
Analyzed expression of transcriptional regulators and signaling pathways associated with neutrophil activation.
Identified four enriched neutrophil subclusters in PSC livers: RHOB-high, immediate early gene-high, heat shock protein-high, and CXCL8-high.
Observed increased activity of TNF and IL-17 signaling pathways in PSC neutrophil subclusters.
Pseudotime analysis indicated immature origins for some subclusters and maturity in others, highlighting program diversity.

Zreka et al. (2026) studied this question.

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