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This research investigates the effectiveness of FAPI imaging for detecting bone metastases in patients with various cancers.

August 13, 2026EJNMMI ResearchOpen Access

Retrospective study of FAPI imaging in bone metastases: diagnostic utility and therapeutic relevance across cancer types in a single-center real-world cohort

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Retrospective study evaluates FAPI imaging diagnostic efficacy in bone metastases, suggesting potential treatment relevance.

This research investigates the effectiveness of FAPI imaging for detecting bone metastases in patients with various cancers.
Retrospective study design with 564 patients screened from June 2021 to September 2023.
Eighty patients with confirmed/suspected bone metastases underwent FAPI imaging and various conventional imaging techniques.
Diagnostic efficacy of FAPI SPECT/CT was compared to CT, MRI, bone scintigraphy, and FDG PET/CT.
FAPI SPECT/CT had a sensitivity of 96.5% and accuracy of 95.9%, significantly outperforming CT (sensitivity 59.7%, accuracy 67.1%, p < 0.001).
FAPI identified new lesions in 46.3% of patients, leading to therapy modifications in 86.5% of cases.
Uptake values of different bone metastasis subtypes showed significant variance, with osteolytic lesions having a median SUV max of 13.41 (p < 0.001).

Li et al. (2026) studied this question.

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