What question did this study set out to answer?

To evaluate the utility of FAPI PET/CT for monitoring fibrotic remodeling and treatment response in myelofibrosis patients undergoing allogeneic stem cell transplantation.

December 8, 2025BloodOpen Access

Fapi PET/CT as an innovative imaging tool for monitoring bone marrow fibrosis and treatment response in myelofibrosis patients undergoing allogeneic stem cell transplantation

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Authors

VPVictoria PanagiotaMedizinische Hochschule Hannover TFThomas Francke MEMatthias EderGerman Cancer Research Center

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Implication

Preliminary analysis shows treatment response in myelofibrosis patients undergoing allogeneic stem cell transplantation, suggesting FAPI PET/CT has diagnostic value.

Key Points

To evaluate the utility of FAPI PET/CT for monitoring fibrotic remodeling and treatment response in myelofibrosis patients undergoing allogeneic stem cell transplantation.
Longitudinal assessment using FAPI PET/CT at pre-transplant, day +100, and day +365.
Analysis included imaging assessments and correlation with clinical outcomes.
Patients underwent various therapies and conditioning regimens prior to transplantation.
13 patients completed baseline imaging; 6 have completed day +100 imaging.
FAPI uptake decreased significantly at multiple bone sites post-transplant, indicating treatment response.
Imaging results showed correlation with histologic regression and improved splenomegaly.

Cite This Study

Panagiota et al. (2025) studied this question.

synapsesocial.com/papers/69362f444fa91c937236d5f7 https://doi.org/10.1182/blood-2025-4303

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Implication

Preliminary analysis shows treatment response in myelofibrosis patients undergoing allogeneic stem cell transplantation, suggesting FAPI PET/CT has diagnostic value.

Fapi PET/CT as an innovative imaging tool for monitoring bone marrow fibrosis and treatment response in myelofibrosis patients undergoing allogeneic stem cell transplantation

Discussion

Member takes

Implication

Key Points

Cite This Study

Fapi PET/CT as an innovative imaging tool for monitoring bone marrow fibrosis and treatment response in myelofibrosis patients undergoing allogeneic stem cell transplantation

Discussion

Member takes

Implication

Key Points

Cite This Study

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