Key result
Myocardial FAPI uptake (SUVmean) predicted calcified plaques in the left anterior descending artery territory with an area under the curve of 0.786, and correlated with cardiovascular risk factors.
Why the study?
FAP plays a vital role in myocardial injury and fibrosis, prompting investigation into the application of FAPI PET/CT imaging in human myocardial fibrosis and its relationship with clinical factors.
Does myocardial FAPI uptake on PET/CT correlate with cardiovascular risk factors and cardiac function in oncological patients?
Population
Twenty-one oncological patients with visual uptake of FAPI in the myocardium
Design
Retrospective analysis
Authors
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FAPI PET/CT may detect myocardial fibrosis in oncological patients; hypothesis-generating for post-MI remodeling, needs prospective validation.
Observational (n=21)
No
Does myocardial FAPI uptake on PET/CT correlate with cardiovascular risk factors and cardiac function in oncological patients?
Effect estimate: AUC 0.786 (95% CI 0.581-0.99)
p-value: p=0.019
Myocardial FAPI uptake on PET/CT correlates with cardiovascular risk factors, cardiac biomarkers, and reduced LVEF, suggesting its potential to evaluate cardiac fibrosis.
Lyu et al. (2022) conducted an observational in Myocardial fibrosis and cardiovascular disease (n=21). Al18F-NOTA-FAPI-04 PET/CT myocardial uptake was evaluated on Prediction of calcified plaques in the left anterior descending (LAD) artery territory by myocardial FAPI uptake (SUVmean) (AUC 0.786, 95% CI 0.581-0.99, p=0.019). Myocardial FAPI uptake (SUVmean) predicted calcified plaques in the left anterior descending artery territory with an area under the curve of 0.786, and correlated with cardiovascular risk factors.
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