Why the study?
Although FAPI tracers were used to study cardiac remodeling after myocardial infarction in small animals, their ability to evaluate cardiac FAP activity in human hearts was unknown.
Does cardiac FAP activity measured by FAPI-PET-CT correlate with cardiovascular risk factors in patients with metastasized cancer?
Does cardiac FAP activity measured by FAPI-PET-CT correlate with cardiovascular risk factors in patients with metastasized cancer?
FAPI-PET-CT represents a novel imaging modality to investigate cardiac fibroblast activation, demonstrating that high signal intensities correlate with cardiovascular risk factors, metabolic disease, and cardiotoxic cancer therapies.
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Demonstrates the feasibility of noninvasive fibroblast imaging in humans; leaves open whether.
Heckmann et al. (2020) studied this question.
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