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August 13, 2026Scientific ReportsOpen Access

Uncovering COVID-19 dynamics in Tunisian patients: a meta-transcriptomic approach

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Authors

DRDorra RjaibiMKMarwa KhedhiriHJHaifa Jmel

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Overview

Randomized trial characterizes SARS-CoV-2 interactions and microbial compositions in COVID-19 patients, suggesting new therapeutic targets.

Key Points

  • This study aims to explore the interaction between SARS-CoV-2 and the human host in Tunisia, focusing on biomarkers and microbial composition.
  • Conducted meta-transcriptomic analysis on 34 clinical samples from severe, moderate, and control COVID-19 patients.
  • Identified differentially expressed host genes and characterized microbial compositions associated with COVID-19.
  • Utilized integrated approaches to analyze virus-host interactions and microbiome.
  • Identified enhanced innate immune responses and interferon signals with specific candidate genes as disease biomarkers.
  • Revealed a diverse microbial community in COVID-19 patients, showing significant differences between severe and moderate cases.
  • Detected both Omicron and Delta variants in the studied cohort.

Cite This Study

Rjaibi et al. (2026) studied this question.

synapsesocial.com/papers/6a7d76bd2b0e0cff3f640512https://doi.org/10.1038/s41598-026-65381-z
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metatranscriptomic Insights into Host-Microbiome Interactions Underlying Asymptomatic COVID-19 Cases2025
  2. 2Metatranscriptomic insights into host-microbiome interactions underlying asymptomatic COVID-19 cases2026
  3. 3Temporal Evolution of COVID-19 Transmission Indicators in Tunisia During the First Three Years of the Pandemic: A Prospective Descriptive Study, 2020–20222026
  4. 4The Omicron Wave in Tunisia: Dynamic, Diversity, and Phylogenetic Analyses2025
  5. 5Metagenomic next-generation sequencing of nasopharyngeal microbiota in COVID-19 patients with different disease severities2024 · 3 citations