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August 13, 2026PathophysiologyOpen Access

Reproductive and Cardiometabolic Characterization of a Letrozole- and High-Fat Diet-Induced PMOS-like Rat Model: An Experimental Study

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Authors

MMMilica MilinkovićAMAleksandar MaticVJVladimir Jakovljević

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Overview

Experimental study characterizes reproductive and cardiometabolic alterations in a PMOS-like rat model, indicating broader organ impacts.

Key Points

  • To characterize the reproductive and cardiometabolic features associated with a letrozole and high-fat diet-induced PMOS-like phenotype in rats.
  • PMOS-like model induced in rats over 21 days using oral letrozole and a high-fat diet.
  • Assessment of reproductive, hormonal, inflammatory, and morphometric changes.
  • Evaluation of metabolic parameters and oxidative stress markers.
  • PMOS group exhibited increased body weight gain and decreased uterine weight compared to controls.
  • Metabolic assessment showed insulin resistance with elevated triglycerides and reduced HDL levels.
  • Morphometric analysis revealed significant ovarian follicular atresia and alterations in cardiomyocyte structure.

Cite This Study

Milinković et al. (2026) studied this question.

synapsesocial.com/papers/6a7d76bd2b0e0cff3f64053dhttps://doi.org/10.3390/pathophysiology33030061
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