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August 13, 2026Journal of Agricultural and Food Chemistry

Design, Synthesis,Antifungal Activity, and ActionMechanism of Indole–Oxazole Compounds as Potential Fungicides

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Authors

WZWei ZhanZMZhiyang MeiMDMingxia Dan

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Overview

Randomized trial explores antifungal properties of indole-oxazole compounds in agriculture, suggesting novel fungicide applications.

Key Points

  • The study aims to evaluate the synthesis and antifungal activity of indole-oxazole compounds against various fungal pathogens.
  • Synthesize 19 indole-oxazole analogues from 1H-indole-3-carbaldehyde.
  • Conduct bioassays to test activity against fungi Rhizoctonia solani, Botrytis cinerea, and Sclerotinia sclerotiorum.
  • Assess mechanisms of action through membrane permeability tests, SEM, and TEM imaging.
  • Compound Z-2 achieved EC50 values of 7.03 mg/L against Rhizoctonia solani and 13.5 mg/L against Botrytis cinerea.
  • Compound Z-3 demonstrated an EC50 of 6.81 mg/L against Sclerotinia sclerotiorum, indicating strong antifungal activity.
  • Indole-oxazole compounds exhibited low phytotoxicity, suggesting safety for plants.

Cite This Study

Zhan et al. (2026) studied this question.

synapsesocial.com/papers/6a7d76d82b0e0cff3f6408eahttps://doi.org/10.1021/acs.jafc.6c01490
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