Population
Primary cultured neonatal rat cardiomyocytes
Comparison
Chimeric, phosphorothioated antisense… vs Control myocytes
Design
Preclinical
Follow-up
up to 7 days
Authors
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NCX knockdown suppresses Ca2+ transients in neonatal cardiomyocytes; hypothesis-generating for antiarrhythmic strategies pending in vivo validation.
Antisense oligonucleotides effectively knock down the Na+/Ca2+ exchanger in neonatal rat cardiomyocytes, which has a protein half-life of 33 hours, leading to significant physiological changes in calcium handling.
Slodzinski et al. (1998) studied this question.
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