Key result
Epicardial adipose tissue thickness ≥ 0.44 cm was associated with a higher frequency of metabolic syndrome compared to thickness < 0.44 cm (74.5% vs 59.5%, p=0.017) in coronary artery disease.
Why the study?
Visceral obesity is a key link in metabolic syndrome and can affect cardiovascular disease development, motivating the study of epicardial adipose tissue thickness in coronary artery disease patients undergoing coronary bypass surgery.
Is epicardial adipose tissue thickness associated with metabolic syndrome and adverse echocardiographic parameters in patients undergoing coronary bypass surgery?
Cross-Sectional (n=178)
No
Is epicardial adipose tissue thickness associated with metabolic syndrome and adverse echocardiographic parameters in patients undergoing coronary bypass surgery?
Absolute Event Rate: 74.5% vs 59.5%
p-value: p=0.017
Increased epicardial adipose tissue thickness measured by echocardiography is significantly associated with metabolic syndrome and adverse left ventricular remodeling in patients undergoing coronary bypass surgery.
Hypothesis-generating in CAD; prospective studies needed before considering epicardial fat measurement for metabolic syndrome risk.
Visceral obesity is a key link in the metabolic syndrome and can affect the development of cardiovascular diseases. Objective . The aim of the study was to identify the clinical, laboratory and instrumental characteristics of patients with coronary artery disease, to analyze adverse cardiovascular events after coronary bypass surgery, according to the thickness of the epicardial adipose tissue (EAT). Design and methods . The study included 178 patients who underwent coronary bypass surgery. The median values of the thickness of the EAT was 0,4 cm. The patients were divided into 2 groups: group 1 — epicardial fat < 0,44 cm (n = 84) and group 2 — epicardial fat > 0,44 cm (n = 94). Results . The frequency of metabolic syndrome in group 1 was 59,5 %, while in group 2 — 74,5 % (p = 0,017). The thickness of the EAT correlated with blood glucose (r = 0,28, p = 0,003), body mass index (BMI) (r = 0,27, p = 0,010), waist circumference (r = 0,26, p = 0,001). End-diastolic volume of the left ventricle (p = 0,016), stroke volume (p = 0,014), thickness of the interventricular septum (p = 0,010), mass of the left ventricular myocardium (p = 0,048), left ventricular myocardial mass index (p = 0,035) were higher in the group with a higher content of EAT. The metabolic syndrome was a significant predictor of the EAT thickness. Conclusions . The EAT thickness is associated with the metabolic syndrome and its components.
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Mustafina et al. (2023) conducted a cross-sectional in Coronary artery disease (n=178). Epicardial adipose tissue thickness ≥ 0.44 cm vs. Epicardial adipose tissue thickness < 0.44 cm was evaluated on Frequency of metabolic syndrome (p=0.017). Epicardial adipose tissue thickness ≥ 0.44 cm was associated with a higher frequency of metabolic syndrome compared to thickness < 0.44 cm (74.5% vs 59.5%, p=0.017) in coronary artery disease.
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