Population
Isolated perfused mouse hearts and isolated mouse cardiac mitochondria subjected to 35 min global ischaemia…
Comparison
S-nitroso N-acetyl penicillamine perfusion, with… vs Control (no SNAP)
Design
Preclinical
Follow-up
30 min reperfusion
Authors
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Dose-dependent SNAP protection in mice warrants mechanistic follow-up; leaves open translation to human ischaemia/reperfusion injury.
Exogenous nitric oxide provides dose-dependent cardioprotection against ischaemia/reperfusion injury in mouse hearts, mediated by mitochondrial K(ATP) channels and membrane depolarization.
Robert M. Bell (2003) studied this question.
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