Why the study?
Does low-dose benidipine reduce the severity of experimental autoimmune myocarditis in rats?
Population
Rats with or without experimental autoimmune myocarditis (EAM)
Comparison
Oral benidipine 3 mg/kg/day for 3 weeks vs Untreated rats with EAM
Design
Preclinical
Follow-up
3 weeks
Authors
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Hypothesis-generating for benidipine in myocarditis; should not yet influence clinical management.
Does low-dose benidipine reduce the severity of experimental autoimmune myocarditis in rats?
Low-dose benidipine provides cardioprotection in experimental autoimmune myocarditis by suppressing inflammatory cytokines and NO production.
Yuan et al. (2003) studied this question.
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