P2Y1‐receptors in human platelets which are pharmacologically distinct from P2YADP‐receptors
Population
Human washed platelets and Jurkat cells stably transfected with a bovine P2Y1-receptor
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Distinguishes P2Y1 from P2Y(ADP) receptors in platelet calcium signaling; leaves open whether selective targeting alters thrombotic risk.
Structured PICO
P
Population
Human washed platelets and Jurkat cells stably transfected with a bovine P2Y1-receptor
I
Intervention
P2Y1-receptor antagonists (A3P5P, AR-C66096) and adenine nucleotide analogues (2-MeSADP, 2-ClATP, ADP, 2-MeSATP, ATPgammaS, ATP)
O
Outcome
Increases in intracellular calcium concentration ([Ca2+]i)surrogate
This preclinical study demonstrates that human platelets possess P2Y1-receptors that are pharmacologically distinct from P2Y(ADP)-receptors and mediate intracellular calcium increases.
Cite This Study
Fagura et al. (1998) studied this question.