January 1, 1998Thrombosis and Haemostasis

Inhibition of Rat Platelet Aggregation by Mycalolide-B, a Novel Inhibitor of Actin Polymerization with a Different Mechanism of Action from Cytochalasin-D

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Population

Rat platelets (in vitro)

Comparison

Mycalolide-B (0.3 to 10 microM) vs Cytochalasin-D (3 microM) or control

Design

Preclinical

Authors

FAFumitoshi AsaiAzabu University SSShinya SaitoUniversity of Shizuoka HOHiroshi OzakiOsaka Gakuin University

Discussion

Member takes

Implication

May inform novel antiplatelet drug design targeting actin; leaves open translation to human thrombosis models.

Structured PICO

Population

Rat platelets (in vitro)

Intervention

Mycalolide-B (0.3 to 10 microM)

Comparator

Cytochalasin-D (3 microM) or control

Outcome

Platelet aggregation (collagen- and ADP-induced) and actin polymerizationsurrogate

Mycalolide-B inhibits rat platelet activation by interfering with actin polymerization through a mechanism distinct from cytochalasin-D.

Cite This Study

Asai et al. (1998) studied this question.

synapsesocial.com/papers/6a7d8933d0946debe914fdc1 https://doi.org/10.1055/s-0037-1614955

Topics

Dual antiplatelet therapy

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Inhibition of Rat Platelet Aggregation by Mycalolide-B, a Novel Inhibitor of Actin Polymerization with a Different Mechanism of Action from Cytochalasin-D

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Inhibition of Rat Platelet Aggregation by Mycalolide-B, a Novel Inhibitor of Actin Polymerization with a Different Mechanism of Action from Cytochalasin-D

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider