Key result
Addition of 10mM Mg2+ to platelet rich plasma completely inhibited aggregation and markedly inhibited actin polymerization induced by 1 microM ADP.
Mg2+ inhibits ADP-induced platelet aggregation and its associated actin polymerization, providing mechanistic insights into platelet biology.
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No immediate clinical implications for antithrombotic therapy; leaves open magnesium's role in human platelet studies.
Heptinstall et al. (1995) studied this question. Mg2+ was evaluated on Platelet aggregation and actin polymerization. Addition of 10mM Mg2+ to platelet rich plasma completely inhibited aggregation and markedly inhibited actin polymerization induced by 1 microM ADP.
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